US Study Links Asthma Drug Singulair to Severe Mental Health Risks, Including Suicidal Thoughts

Recent findings by U.S. government researchers have raised concerns about the widely prescribed asthma drug Singulair (montelukast), linking it to severe mental health side effects in some patients. According to a scientific presentation at the American College of Toxicology, montelukast has been shown to bind to key brain receptors associated with psychiatric functions, potentially contributing to adverse effects.

Key Points:

• Serious Side Effects Reported: Thousands of cases involving depression, suicidal thoughts, and behavioral changes have been reported to the FDA since Singulair’s launch in 1998. These include at least 82 suicides, with 31 cases involving individuals aged 19 or younger.
• Scientific Findings: Research indicates that montelukast penetrates brain regions critical to mood, cognition, and impulse control. FDA tests reveal significant binding of the drug to brain receptors, similar to medications known to cause neuropsychiatric effects.
• FDA Response: In 2020, the FDA added a “black box” warning to Singulair’s label, highlighting serious mental health risks. The agency does not currently plan to update the label further but acknowledges the need for additional research.
• Personal Stories: Families affected by adverse reactions, such as Robert England, whose 22-year-old son died by suicide shortly after taking the drug, are advocating for more awareness and caution in prescribing montelukast.

What’s Next?

While montelukast remains a commonly prescribed medication for asthma and allergies, patients and healthcare providers are urged to weigh the potential benefits against the risks, particularly for individuals with no prior history of mental health issues.

Organon, which markets Singulair, maintains confidence in its safety profile but emphasizes the importance of following the prescribing information.

For those prescribed montelukast, monitoring for any signs of mood changes, depression, or suicidal thoughts is crucial. Patients experiencing such symptoms should consult their healthcare provider immediately.

Stay informed about updates on this ongoing investigation.